GW 9508

• Supplier: Tocris Bioscience
• Catalog: 2977
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 885101-89-3
• Chemical Name: 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoicacid
• Formula: C22H21NO3
• Molecular Weight: 347.41
• Purity: >99 %
• Description: Potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) (pEC 50 values are 7.32, < 4.3 and < 4.3 for FFA1, FFA2 and FFA3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC 50 = 6.14).

Product References

Pharmacological regulation of insulin secretion in MIN6 cells through the fatty - Pharmacological regulation of insulin secretion in MIN6 cells through the fatty

Briscoe CP, Peat AJ, McKeown SC, Corbett DF, Goetz AS, Littleton TR, McCoy DC, Kenakin TP, Andrews JL, Ammala C, Fornwald JA, Ignar DM, Jenkinson S. Br J Pharmacol. 2006 Jul;148(5):619-28. Epub 2006 May 15.

Synthesis and activity of small molecule GPR40 agonists. - Synthesis and activity of small molecule GPR40 agonists.

Garrido DM, Corbett DF, Dwornik KA, Goetz AS, Littleton TR, McKeown SC, Mills WY, Smalley TL Jr, Briscoe CP, Peat AJ. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1840-5. Epub 2006 Jan 24.

Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by - Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by

Zhao YF, Pei J, Chen C. J Endocrinol. 2008 Sep;198(3):533-40.