GW 9662

• Supplier: Tocris Bioscience
• Catalog: 2649
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 22978-25-2
• Chemical Name: 2-Chloro-5-nitro-N-phenylbenzamide
• Formula: C13H9N2O3Cl
• Molecular Weight: 276.68
• Purity: >98 %
• Description: Selective PPAR γ antagonist (IC 50 values are 3.3, 32 and 2000 nM for PPAR γ , PPAR α and PPAR δ respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 μ M), therefore is more potent than BADGE (Cat. No. 1326). Anticancer, inhibits growth of human mammary tumor cell lines.

Product References

IL-4 inhibits osteoclast formation through a direct action on osteoclast - IL-4 inhibits osteoclast formation through a direct action on osteoclast

Bendixen AC, Shevde NK, Dienger KM, Willson TM, Funk CD, Pike JW. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2443-8. Epub 2001 Feb 20.

Functional consequences of cysteine modification in the ligand binding sites of - Functional consequences of cysteine modification in the ligand binding sites of

Leesnitzer LM, Parks DJ, Bledsoe RK, Cobb JE, Collins JL, Consler TG, Davis RG, Hull-Ryde EA, Lenhard JM, Patel L, Plunket KD, Shenk JL, Stimmel JB, Therapontos C, Willson TM, Blanchard SG. Biochemistry. 2002 May 28;41(21):6640-50.

GW9662, a potent antagonist of PPARgamma, inhibits growth of breast tumour cells - GW9662, a potent antagonist of PPARgamma, inhibits growth of breast tumour cells

Seargent JM, Yates EA, Gill JH. Br J Pharmacol. 2004 Dec;143(8):933-7. Epub 2004 Nov 8.