GYKI 52466 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3099
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 102771-26-6
• Chemical Name: 4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-benzenaminedihydrochloride
• Formula: C17H15N3O2.2HCl
• Molecular Weight: 366.24
• Purity: >98 %
• Description: Selective non-competitive AMPA receptor antagonist (IC 50 values are 10-20, ~ 450 and >> 50 μ M for AMPA- , kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. Has anti-proliferative effects in transformed cells. Also available as part of the AMPA Receptor Tocriset™ . Also available as part of the Kainate Receptor Tocriset™ .

Product References

Electrophysiological studies with a 2,3-benzodiazepine muscle relaxant: GYKI - Electrophysiological studies with a 2,3-benzodiazepine muscle relaxant: GYKI

Tarnawa I, Farkas S, Berzsenyi P, Pataki A, Andrasi F. Eur J Pharmacol. 1989 Aug 22;167(2):193-9.

GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive - GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive

Donevan SD, Rogawski MA. Neuron. 1993 Jan;10(1):51-9.

Selective antagonism of AMPA receptors unmasks kainate receptor-mediated - Selective antagonism of AMPA receptors unmasks kainate receptor-mediated

Paternain AV, Morales M, Lerma J. Neuron. 1995 Jan;14(1):185-9.

Glutamate antagonists limit tumor growth. - Glutamate antagonists limit tumor growth.

Rzeski W, Turski L, Ikonomidou C. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6372-7. Epub 2001 May 1.

Comparison of anticonvulsive and acute neuroprotective activity of three - Comparison of anticonvulsive and acute neuroprotective activity of three

Szabados T, Gigler G, Gacsalyi I, Gyertyan I, Levay G. Brain Res Bull. 2001 Jun;55(3):387-91.