H-7 dihydrochloride

Name H-7 dihydrochloride
Supplier Tocris Bioscience
Catalog 4878
Prices $129.00, $535.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 108930-17-2
Chemical Name (±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazinedihydrochloride
Formula C14H17N3O2S.2HCl
Molecular Weight 364.29
Purity >99 %
Description Protein kinase inhibitor. IC 50 values for inhibition of PKC, PKG, PKA and myosin light chain kinase are 6.0, 5.8, 3.0 and 97.0 μ M respectively.
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Product References

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide - Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide

Hidaka H, Inagaki M, Kawamoto S, Sasaki Y. Biochemistry. 1984 Oct 9;23(21):5036-41.

Effect of the kinase inhibitor, H-7, on stress, crossbridge phosphorylation, - Effect of the kinase inhibitor, H-7, on stress, crossbridge phosphorylation,

Ratz PH. J Pharmacol Exp Ther. 1990 Jan;252(1):253-9.

Modulation of inhibitory efficiency of rat skeletal muscle calpastatin by - Modulation of inhibitory efficiency of rat skeletal muscle calpastatin by

Pontremoli S, Viotti PL, Michetti M, Salamino F, Sparatore B, Melloni E. Biochem Biophys Res Commun. 1992 Sep 16;187(2):751-9.