HA 130

• Supplier: Tocris Bioscience
• Catalog: 2415
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1229652-21-4
• Chemical Name: B-[3-[[4-[[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronicacid
• Formula: C24H19BFNO5S
• Molecular Weight: 463.29
• Purity: >98 %
• Description: Selective autotaxin inhibitor (IC 50 = 28 nM). Binds and inhibits autotaxin reversibly. Displays no activity against the proteasome, recombinant NPP1 or alkaline phosphatase. Inhibits ATX-mediated cell migration in an A2058 melanoma cell assay.

Product References

Discovery and optimization of boronic acid based inhibitors of autotaxin. - Discovery and optimization of boronic acid based inhibitors of autotaxin.

Albers HM, van Meeteren LA, Egan DA, van Tilburg EW, Moolenaar WH, Ovaa H. J Med Chem. 2010 Jul 8;53(13):4958-67.

Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the - Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the

Albers HM, Dong A, van Meeteren LA, Egan DA, Sunkara M, van Tilburg EW, Schuurman K, van Tellingen O, Morris AJ, Smyth SS, Moolenaar WH, Ovaa H. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7257-62. doi: