HA14-1

• Supplier: Tocris Bioscience
• Catalog: 4196
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 65673-63-4
• Chemical Name: 2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacidethylester
• Formula: C17H17BrN2O5
• Molecular Weight: 409.23
• Description: Cell-permeable inhibitor of Bcl-2 protein (IC 50 ~ 9 μ M); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells. Also binds to the antiapoptotic Blc-2 proteins Bcl-XL and Bcl-w.

Product References

Structure-based discovery of an organic compound that binds Bcl-2 protein and - Structure-based discovery of an organic compound that binds Bcl-2 protein and

Wang JL, Liu D, Zhang ZJ, Shan S, Han X, Srinivasula SM, Croce CM, Alnemri ES, Huang Z. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7124-9.

Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and - Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and

Milella M, Estrov Z, Kornblau SM, Carter BZ, Konopleva M, Tari A, Schober WD, Harris D, Leysath CE, Lopez-Berestein G, Huang Z, Andreeff M. Blood. 2002 May 1;99(9):3461-4.

Structure-activity relationship studies of ethyl - Structure-activity relationship studies of ethyl

Doshi JM, Tian D, Xing C. J Med Chem. 2006 Dec 28;49(26):7731-9.