Herbimycin A

Name Herbimycin A
Supplier Tocris Bioscience
Catalog 3174
Prices $175.00
Sizes 100 µg
Function Type Inhibitor
Cas Number 70563-58-5
Chemical Name (15R)-17-demethoxy-15-methoxy-11-O-methyl-geldanamycin
Formula C30H42N2O9
Molecular Weight 574.67
Purity >99 %
Description Ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60 v-src and p210 BCR-ABL . Exhibits antiangiogenic activity in endothelial cells in vitro . Also inhibits Hsp90 and impairs recovery from heat shock.
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Product References

Labeling of v-Src and BCR-ABL tyrosine kinases with [14C]herbimycin A and its use - Labeling of v-Src and BCR-ABL tyrosine kinases with [14C]herbimycin A and its use

Fukazawa H, Uehara Y, Murakami Y, Mizuno S, Hamada M, Takeuchi T. FEBS Lett. 1994 Mar 7;340(3):155-8.

Herbimycin A inhibits angiogenic activity in endothelial cells and reduces - Herbimycin A inhibits angiogenic activity in endothelial cells and reduces

McCollum GW, Rajaratnam VS, Bullard LE, Yang R, Penn JS. Exp Eye Res. 2004 May;78(5):987-95.

Inhibition of Hsp90 function delays and impairs recovery from heat shock. - Inhibition of Hsp90 function delays and impairs recovery from heat shock.

Duncan RF. FEBS J. 2005 Oct;272(20):5244-56.