Hesperadin hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1629
• Prices: $265.00, $1,085.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 422513-13-1
• Chemical Name: N-[2,3-Dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]-ethanesulfonamidehydrochloride
• Formula: C29H32N4O3S.HCl
• Molecular Weight: 553.12
• Purity: >99 %
• Description: ATP-competitive inhibitor of Aurora B kinase (IC 50 = 250 nM). Prevents chromosome alignment and segregation; also induces polyploidy and prevents histone H3-Ser10 phosphorylation. Overrides the spindle assembly checkpoint and induces mitotic exit in monastrol - and taxol -treated HeLa cells.

Product References

The small molecule Hesperadin reveals a role for Aurora B in correcting - The small molecule Hesperadin reveals a role for Aurora B in correcting

Hauf S, Cole RW, LaTerra S, Zimmer C, Schnapp G, Walter R, Heckel A, van Meel J, Rieder CL, Peters JM. J Cell Biol. 2003 Apr 28;161(2):281-94. Epub 2003 Apr 21.

Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. - Mechanism of Aurora B activation by INCENP and inhibition by hesperadin.

Sessa F, Mapelli M, Ciferri C, Tarricone C, Areces LB, Schneider TR, Stukenberg PT, Musacchio A. Mol Cell. 2005 Apr 29;18(3):379-91.

The cell cycle as a therapeutic target against Trypanosoma brucei: Hesperadin - The cell cycle as a therapeutic target against Trypanosoma brucei: Hesperadin

Jetton N, Rothberg KG, Hubbard JG, Wise J, Li Y, Ball HL, Ruben L. Mol Microbiol. 2009 Apr;72(2):442-58.