HI TOPK 032

• Supplier: Tocris Bioscience
• Catalog: 5627
• Prices: $225.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 487020-03-1
• Chemical Name: N-(12-Cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide
• Formula: C20H11N5OS
• Molecular Weight: 369.4
• Purity: >98 %
• Description: T-LAK-cell-originated protein kinase (TOPK) inhibitor; exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC 50 = 9.6 μ M).

Product References

Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on - Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on

Li Y, Kim DJ, Ma W, Lubet RA, Bode AM, Dong Z. J Chem Inf Model. 2011 Nov 28;51(11):2904-14.

Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. - Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth.

Kim DJ, Li Y, Reddy K, Lee MH, Kim MO, Cho YY, Lee SY, Kim JE, Bode AM, Dong Z. Cancer Res. 2012 Jun 15;72(12):3060-8.