HIOC

• Supplier: Tocris Bioscience
• Catalog: 2994
• Prices: $125.00, $525.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 314054-36-9
• Chemical Name: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide
• Formula: C16H19N3O3
• Molecular Weight: 301.34
• Purity: >98 %
• Description: Selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo . Blood brain barrier and blood-retinal barrier penetrant.

Product References

Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists. - Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists.

Conti P, De Amici M, De Sarro G, Rizzo M, Stensbol TB, Brauner-Osborne H, Madsen U, Toma L, De Micheli C. J Med Chem. 1999 Oct 7;42(20):4099-107.

Dissociation of [3H]L-glutamate uptake from L-glutamate-induced [3H]D-aspartate - Dissociation of [3H]L-glutamate uptake from L-glutamate-induced [3H]D-aspartate

Funicello M, Conti P, De Amici M, De Micheli C, Mennini T, Gobbi M. Mol Pharmacol. 2004 Sep;66(3):522-9.