Hispidulin

• Supplier: Tocris Bioscience
• Catalog: 2218
• Prices: $229.00
• Sizes: 10 mg
• Function Type: Modulator
• Cas Number: 1447-88-7
• Chemical Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
• Formula: C16H12O6
• Molecular Weight: 300.27
• Purity: >98 %
• Description: Partial positive allosteric modulator at the benzodiazepine receptor (IC 50 = 1.3 μ M for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α 1-, α 2-, α 3-, α 5- or α 6- β 2 γ 2S GABA A receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties.

Product References

Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing - Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing

Bourdillat B, Delautier D, Labat C, Benveniste J, Potier P, Brink C. Eur J Pharmacol. 1988 Feb 16;147(1):1-6.

Constituents of sage (Salvia officinalis) with in vitro affinity to human brain - Constituents of sage (Salvia officinalis) with in vitro affinity to human brain

Kavvadias D, Monschein V, Sand P, Riederer P, Schreier P. Planta Med. 2003 Feb;69(2):113-7.

The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric - The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric

Kavvadias D, Sand P, Youdim KA, Qaiser MZ, Rice-Evans C, Baur R, Sigel E, Rausch WD, Riederer P, Schreier P. Br J Pharmacol. 2004 Jul;142(5):811-20.