HKI 357

• Supplier: Tocris Bioscience
• Catalog: 4844
• Prices: $255.00, $1,045.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 848133-17-5
• Chemical Name: (2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
• Formula: C31H29ClFN5O3
• Molecular Weight: 574.05
• Purity: >98 %
• Description: Potent, irreversible inhibitor of ErbB2 (HER2) and EGFR (IC 50 values are 33 and 34 nM respectively). Suppresses ligand-induced EGFR autophosphorylation and cell proliferation in NCI-H1975 cells containing L858R and T790M mutations. Circumvents mechanisms of resistance to Iressa (Cat. No. 3000) in non-small-cell lung cancer cells.

Product References

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