HLI 373

Name HLI 373
Supplier Tocris Bioscience
Catalog 3580
Prices $155.00, $645.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 502137-98-6
Chemical Name 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dionedihydrochloride
Formula C18H23N5O2.2HCl
Molecular Weight 414.33
Purity >99 %
Description Inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.
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Product References

Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. - Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.

Kitagaki J, Agama KK, Pommier Y, Yang Y, Weissman AM. Mol Cancer Ther. 2008 Aug;7(8):2445-54.

Targeting the ubiquitin-proteasome system for cancer therapy. - Targeting the ubiquitin-proteasome system for cancer therapy.

Yang Y, Kitagaki J, Wang H, Hou DX, Perantoni AO. Cancer Sci. 2009 Jan;100(1):24-8.