HLM 006474

• Supplier: Tocris Bioscience
• Catalog: 3503
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 353519-63-8
• Chemical Name: 7-[(4-Ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-8-quinolinol
• Formula: C25H25N3O2
• Molecular Weight: 399.48
• Purity: >98 %
• Description: E2F transcription factor inhibitor; inhibits E2F DNA binding activity. Inhibits E2F4 DNA binding and reduces E2F4 protein levels in A375 melanoma cells. Induces apoptosis of A375 and MDA-MB-231 breast cancer cells. Inhibits A375 proliferation and invasion in a three dimensional skin model of A375 invasion. Also attenuates human embryonic stem cell proliferation.

Product References

A small-molecule E2F inhibitor blocks growth in a melanoma culture model. - A small-molecule E2F inhibitor blocks growth in a melanoma culture model.

Ma Y, Kurtyka CA, Boyapalle S, Sung SS, Lawrence H, Guida W, Cress WD. Cancer Res. 2008 Aug 1;68(15):6292-9.

The RB family is required for the self-renewal and survival of human embryonic - The RB family is required for the self-renewal and survival of human embryonic

Conklin JF, Baker J, Sage J. Nat Commun. 2012;3:1244.