HM 50316

• Supplier: Tocris Bioscience
• Catalog: 5283
• Prices: $195.00, $819.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1310361-52-4
• Chemical Name: 2-[[2'-[1-(4-Chlorophenyl)-5-(2-thienyl)-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]oxy]-2-methylpropanoicacid
• Formula: C29H23ClN2O3S
• Molecular Weight: 515.02
• Purity: >98 %
• Description: High affinity FABP4 inhibitor (K i < 1 nM). Highly selective for FABP4 over FABP3. Inhibits LPS-induced activation of murine macrophages in vitro .

Product References

Synthesis and activity of novel and selective I(Ks)-channel blockers. - Synthesis and activity of novel and selective I(Ks)-channel blockers.

Gerlach U, Brendel J, Lang HJ, Paulus EF, Weidmann K, Bruggemann A, Busch AE, Suessbrich H, Bleich M, Greger R. J Med Chem. 2001 Nov 8;44(23):3831-7.

HMR 1556, a potent and selective blocker of slowly activating delayed rectifier - HMR 1556, a potent and selective blocker of slowly activating delayed rectifier

Thomas GP, Gerlach U, Antzelevitch C. J Cardiovasc Pharmacol. 2003 Jan;41(1):140-7.

Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not - Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not

Michael G, Dempster J, Kane KA, Coker SJ. Br J Pharmacol. 2007 Dec;152(8):1215-27. Epub 2007 Oct 29.