Homoharringtonine

• Supplier: Tocris Bioscience
• Catalog: 5117
• Prices: $165.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 26833-87-4
• Chemical Name: Cephalotaxine4-methyl(2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
• Formula: C29H39NO9
• Molecular Weight: 545.63
• Purity: >99 %
• Description: Inhibitor of protein synthesis. Blocks elongation phase of translation by binding to the 60-S ribosome subunit. Antileukemic.

Product References

Inhibition of translation in eukaryotic systems by harringtonine. - Inhibition of translation in eukaryotic systems by harringtonine.

Fresno M, Jimenez A, Vazquez D. Eur J Biochem. 1977 Jan;72(2):323-30.

Homoharringtonine: an effective new natural product in cancer chemotherapy. - Homoharringtonine: an effective new natural product in cancer chemotherapy.

Zhou DC, Zittoun R, Marie JP. Bull Cancer. 1995 Dec;82(12):987-95.

Apoptotic response to homoharringtonine in human wt p53 leukemic cells is - Apoptotic response to homoharringtonine in human wt p53 leukemic cells is

Cai Z, Lin M, Wuchter C, Ruppert V, Dorken B, Ludwig WD, Karawajew L. Leukemia. 2001 Apr;15(4):567-74.