| Name | HPI 1 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4590 |
| Prices | $175.00, $709.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 599150-20-6 |
| Chemical Name | 1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylicacid2-methoxyethylester |
| Formula | C27H29NO6 |
| Molecular Weight | 463.52 |
| Purity | >95 % |
| Description | Hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC 50 values are 1.5, 1.5, 4 and 6 μ M for Shh-, SAG-, Gli2- and Gli1-induced activation). Also inhibits Hh pathway activation in SmoM2-LIGHT cells (IC 50 = 2.5 μ M); inhibits the proliferation of cerebellar granule neuron precursors expressing SmoM2. Does not inhibit Wnt signaling. |
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