HQL 79

• Supplier: Tocris Bioscience
• Catalog: 3839
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 162641-16-9
• Chemical Name: 4-(Diphenylmethoxy)-1-(3-2H-tetrazol-5-yl)propyl]-piperidine
• Formula: C22H27N5O
• Molecular Weight: 377.48
• Purity: >99 %
• Description: Orally active and specific inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS) (IC 50 = 6 μ M). Antiallergic and anti-inflammatory; displays antiasthmatic activity and potent antihistaminic properties in vivo .

Product References

Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of - Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of

Matsushita N, Aritake K, Takada A, Hizue M, Hayashi K, Mitsui K, Hayashi M, Hirotsu I, Kimura Y, Tani T, Nakajima H. Jpn J Pharmacol. 1998 Sep;78(1):11-22.

Structural and functional characterization of HQL-79, an orally selective - Structural and functional characterization of HQL-79, an orally selective

Aritake K, Kado Y, Inoue T, Miyano M, Urade Y. J Biol Chem. 2006 Jun 2;281(22):15277-86. Epub 2006 Mar 17.

Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis - Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis

Mohri I, Taniike M, Taniguchi H, Kanekiyo T, Aritake K, Inui T, Fukumoto N, Eguchi N, Kushi A, Sasai H, Kanaoka Y, Ozono K, Narumiya S, Suzuki K, Urade Y. J Neurosci. 2006 Apr 19;26(16):4383-93.