4-HQN

• Supplier: Tocris Bioscience
• Catalog: 3530
• Prices: $95.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 491-36-1
• Chemical Name: 4-(1H)-Quinazolinone
• Formula: C8H6N2O
• Molecular Weight: 146.15
• Purity: >99 %
• Description: Inhibitor of poly(ADP-ribose) polymerase (PARP) (IC 50 = 9.5 μ M); displays mixed inhibition with respect to NAD + . Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Anti-inflammatory in LPS-induced endotoxic mice in vivo ; decreases NF- κ B and AP-1 activation.

Product References

Specific inhibitors of poly(ADP-ribose) synthetase and - Specific inhibitors of poly(ADP-ribose) synthetase and

Banasik M, Komura H, Shimoyama M, Ueda K. J Biol Chem. 1992 Jan 25;267(3):1569-75.

Effect of poly(ADP-ribose) polymerase inhibitors on the - Effect of poly(ADP-ribose) polymerase inhibitors on the

Halmosi R, Berente Z, Osz E, Toth K, Literati-Nagy P, Sumegi B. Mol Pharmacol. 2001 Jun;59(6):1497-505.

Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) - Regulation of kinase cascades and transcription factors by a poly(ADP-ribose)

Veres B, Radnai B, Gallyas F Jr, Varbiro G, Berente Z, Osz E, Sumegi B. J Pharmacol Exp Ther. 2004 Jul;310(1):247-55. Epub 2004 Mar 3.