HS 014

Name HS 014
Supplier Tocris Bioscience
Catalog 2192
Prices $309.00
Sizes 1 mg
Function Type Antagonist
Cas Number 207678-81-7
Formula C71H94N20O17S2
Molecular Weight 1563.77
Description Potent and selective melanocortin MC 4 receptor antagonist (K i values are 3.16, 108, 54.4 and 694 nM for cloned human MC 4 , MC 1 , MC 3 and MC 5 receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo . Also inhibits IL-1 β -induced Fos expression in the paraventricular hypothalamus.
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Product References

Discovery of novel melanocortin4 receptor selective MSH analogues. - Discovery of novel melanocortin4 receptor selective MSH analogues.

Schioth HB, Mutulis F, Muceniece R, Prusis P, Wikberg JE. Br J Pharmacol. 1998 May;124(1):75-82.

Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity - Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity

Bellasio S, Nicolussi E, Bertorelli R, Reggiani A. Eur J Pharmacol. 2003 Dec 15;482(1-3):127-32.

Central blockade of melanocortin receptors attenuates the metabolic and locomotor - Central blockade of melanocortin receptors attenuates the metabolic and locomotor

Whitaker KW, Reyes TM. Neuropharmacology. 2008 Mar;54(3):509-20. Epub 2007 Nov 5.