HS 024

Name HS 024
Supplier Tocris Bioscience
Catalog 1831
Prices $309.00
Sizes 1 mg
Function Type Antagonist
Cas Number 212370-59-7
Formula C58H79N19O10S2
Molecular Weight 1266.5
Description Highly potent melanocortin MC 4 receptor antagonist (K i values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC 4 , MC 1 , MC 3 and MC 5 receptors respectively). Increases food intake, and blocks α -MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo .
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Product References

Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist - Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist

Kask A, Mutulis F, Muceniece R, Pahkla R, Mutule I, Wikberg JE, Rago L, Schioth HB. Endocrinology. 1998 Dec;139(12):5006-14.

Melanocortin receptor agonist transiently increases oxygen consumption in rats. - Melanocortin receptor agonist transiently increases oxygen consumption in rats.

Jonsson L, Skarphedinsson JO, Skuladottir GV, Atlason PT, Eiriksdottir VH, Franzson L, Schioth HB. Neuroreport. 2001 Dec 4;12(17):3703-8.

Food conversion is transiently affected during 4-week chronic administration of - Food conversion is transiently affected during 4-week chronic administration of

Jonsson L, Skarphedinsson JO, Skuladottir GV, Watanobe H, Schioth HB. J Endocrinol. 2002 Jun;173(3):517-23.