HTH 01-015

Name HTH 01-015
Supplier Tocris Bioscience
Catalog 1832
Prices $179.00, $745.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 1613724-42-7
Chemical Name 5,13-Dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one
Formula C26H28N8O
Molecular Weight 468.55
Purity >98 %
Description Potent and selective NUAK1 inhibitor (IC 50 = 100 nM). Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. Inhibits NUAK1-mediated MYPT1 phosphorylation. Also inhibits cell proliferation in U2OS cells in vitro , to a similar extent as NUAK1 knockdown models.
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Product References

The effects of derivatives of histamine on natural suppressor cells. - The effects of derivatives of histamine on natural suppressor cells.

Khan MM, Marr-Leisy D, Verlander MS, Bristow MR, Strober S, Goodman M, Melmon KL. J Immunol. 1986 Jul 1;137(1):308-14.

Congener derivatives and conjugates of histamine: synthesis and tissue and - Congener derivatives and conjugates of histamine: synthesis and tissue and

Khan MM, Melmon KL, Marr-Leisy D, Verlander MS, Egli M, Lok S, Goodman M. J Med Chem. 1987 Nov;30(11):2115-20.