HU 211

• Supplier: Tocris Bioscience
• Catalog: 0966
• Prices: $379.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 112924-45-5
• Chemical Name: (6aS,10aS)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol
• Formula: C25H38O3
• Molecular Weight: 386.57
• Purity: >97 %
• Description: NMDA antagonist (IC 50 = 11 μ M for inhibition of [ 3 H]MK-801 binding to rat forebrain membranes). Protects against NMDA- and quisqualate-induced neurotoxicity (EC 50 = 3.8 μ M) and enhances dopamine D 1 receptor activity. Inhibits NF- κ B, reducing TNF- α , IL-6 and nitric oxide production, and acts as a free radical scavenger. Exhibits beneficial effects in experimental models of multiple sclerosis, bacterial meningitis, septic shock, epilepsy, and traumatic and ischemic brain injury. Brain penetrant.

Product References

HU-211, a non-psychotropic cannabinoid, rescues cortical neurones from excitatory - HU-211, a non-psychotropic cannabinoid, rescues cortical neurones from excitatory

Eshhar N, Striem S, Biegon A. Neuroreport. 1993 Dec 13;5(3):237-40.

Protection against septic shock and suppression of tumor necrosis factor alpha - Protection against septic shock and suppression of tumor necrosis factor alpha

Gallily R, Yamin A, Waksmann Y, Ovadia H, Weidenfeld J, Bar-Joseph A, Biegon A, Mechoulam R, Shohami E. J Pharmacol Exp Ther. 1997 Nov;283(2):918-24.

Interaction of dexanabinol (HU-211), a novel NMDA receptor antagonist, with the - Interaction of dexanabinol (HU-211), a novel NMDA receptor antagonist, with the

Striem S, Bar-Joseph A, Berkovitch Y, Biegon A. Eur J Pharmacol. 1997 Nov 12;338(3):205-13.

The cannabinoid dexanabinol is an inhibitor of the nuclear factor-kappa B - The cannabinoid dexanabinol is an inhibitor of the nuclear factor-kappa B

Juttler E, Potrovita I, Tarabin V, Prinz S, Dong-Si T, Fink G, Schwaninger M. Neuropharmacology. 2004 Sep;47(4):580-92.