HU 308

• Supplier: Tocris Bioscience
• Catalog: 2861
• Prices: $255.00, $1,045.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 256934-39-1
• Chemical Name: 4-[4-(1,1-Dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol
• Formula: C27H42O3
• Molecular Weight: 414.62
• Purity: >98 %
• Description: Potent and selective CB 2 receptor agonist (K i values are 22.7 nM and > 10 μ M for CB 2 and CB 1 receptors respectively, EC 50 = 5.57 nM). Displays antiallodynic activity in the rat hindpaw incision model of postoperative pain. Also neuroprotective and improves motor performance in a mouse model of Huntington's Disease.

Product References

HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor. - HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor.

Hanus L, Breuer A, Tchilibon S, Shiloah S, Goldenberg D, Horowitz M, Pertwee RG, Ross RA, Mechoulam R, Fride E. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14228-33.

Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of - Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of

LaBuda CJ, Koblish M, Little PJ. Eur J Pharmacol. 2005 Dec 19;527(1-3):172-4. Epub 2005 Nov 28.

Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease - Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease

Palazuelos J, Aguado T, Pazos MR, Julien B, Carrasco C, Resel E, Sagredo O, Benito C, Romero J, Azcoitia I, Fernandez-Ruiz J, Guzman M, Galve-Roperh I. Brain. 2009 Nov;132(Pt 11):3152-64.