Huwentoxin IV

Name Huwentoxin IV
Supplier Tocris Bioscience
Catalog 3088
Prices $209.00
Sizes 100 µg
Function Type Blocker
Cas Number 526224-73-7
Formula C174H278N52O51S6
Molecular Weight 4106.79
Description Selective Na V 1.7 channel blocker. Preferentially inhibits neuronal Na V 1.7, 1.2 and 1.3 (IC 50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes Na V 1.4 and 1.5 (IC 50 = >10 μ M). Inhibits the channel by binding at the neurotoxin receptor site 4 in the S3-S4 linker of domain II, trapping the voltage sensor in the inward, closed configuration.
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Product References

Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor - Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor

Xiao Y, Bingham JP, Zhu W, Moczydlowski E, Liang S, Cummins TR. J Biol Chem. 2008 Oct 3;283(40):27300-13.

Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ - Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+

Xiao Y, Jackson JO 2nd, Liang S, Cummins TR. J Biol Chem. 2011 Aug 5;286(31):27301-10.