Name | HX 531 |
---|---|
Supplier | Tocris Bioscience |
Catalog | 5235 |
Prices | $225.00, $925.00 |
Sizes | 10 mg, 50 mg |
Function Type | Antagonist |
Cas Number | 188844-34-0 |
Chemical Name | 4-(7,8,9,10-Tetrahydro-5,7,7,10.10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]-diazepin-12-yl)-benzoicacid |
Formula | C29H29N3O4 |
Molecular Weight | 483.56 |
Purity | >98 % |
Description | Potent RXR antagonist (IC 50 = 18 nM). Promotes white and brown pre-adipocyte differentiation into white adipocytes. Also inhibits bexarotene -induced brown adipogenic reprogramming of myoblasts. |
Supplier Page | Shop |
Ebisawa M, Umemiya H, Ohta K, Fukasawa H, Kawachi E, Christoffel G, Gronemeyer H, Tsuji M, Hashimoto Y, Shudo K, Kagechika H. Chem Pharm Bull (Tokyo). 1999 Dec;47(12):1778-86.
Alique M, Lucio FJ, Herrero JF. Br J Pharmacol. 2006 Sep;149(1):65-72. Epub 2006 Jul 17.
Suzuki K, Takahashi K, Nishimaki-Mogami T, Kagechika H, Yamamoto M, Itabe H. Biol Pharm Bull. 2009 Jul;32(7):1177-82.