Hydroxy Dynasore

• Supplier: Tocris Bioscience
• Catalog: 4093
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1256493-34-1
• Chemical Name: 3-Hydroxynaphthalene-2-carboxylicacid2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide
• Formula: C18H14N2O5
• Molecular Weight: 338.31
• Purity: >98 %
• Description: Dynamin inhibitor (IC 50 values are 0.38 and 2.6 μ M for dynamin 1 and 2 respectively). Inhibits dynamin-mediated endocytosis in multiple cell types and reduces synaptic vesicle endocytosis in vitro . Prevents botulinum A internalization in hippocampal neurons. Also protects against botulinum A-induced muscle paralysis in rats. Analog of Dynasore (Cat. No. 2897).

Product References

Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and - Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and

Harper CB, Martin S, Nguyen TH, Daniels SJ, Lavidis NA, Popoff MR, Hadzic G, Mariana A, Chau N, McCluskey A, Robinson PJ, Meunier FA. J Biol Chem. 2011 Oct 14;286(41):35966-76.

Building a better dynasore: the dyngo compounds potently inhibit dynamin and - Building a better dynasore: the dyngo compounds potently inhibit dynamin and

McCluskey A, Daniel JA, Hadzic G, Chau N, Clayton EL, Mariana A, Whiting A, Gorgani NN, Lloyd J, Quan A, Moshkanbaryans L, Krishnan S, Perera S, Chircop M, von Kleist L, McGeachie AB, Howes MT, Parton RG, Campbell M, Sakoff JA, Wang X, Sun JY, Robertson MJ, Deane FM, Nguyen TH, Meunier FA, Cousin MA, Robinson PJ. Traffic. 2013 Dec;14(12):1272-89.