20( S )-Hydroxycholesterol

• Supplier: Tocris Bioscience
• Catalog: 5648
• Prices: $165.00
• Sizes: 10 mg
• Function Type: Activator
• Cas Number: 516-72-3
• Chemical Name: (3β)-Cholest-5-ene-3,20-diol
• Formula: C27H46O2
• Molecular Weight: 402.65
• Purity: >95 %
• Description: Allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein; binds at a site distinct from the canonical cyclopamine binding site. Activates Hedgehog (Hh) signaling (EC 50 ~ 3 μ M for induction of Hh reporter gene transcription in in NIH 3T3 cells). Induces Smo accumulation in primary cilia; also exhibits osteogenic activity and activates the liver X receptor (LXR).

Product References

Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent - Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent

Dwyer JR, Sever N, Carlson M, Nelson SF, Beachy PA, Parhami F. J Biol Chem. 2007 Mar 23;282(12):8959-68. Epub 2007 Jan 2.

Oxysterols are allosteric activators of the oncoprotein Smoothened. - Oxysterols are allosteric activators of the oncoprotein Smoothened.

Nachtergaele S, Mydock LK, Krishnan K, Rammohan J, Schlesinger PH, Covey DF, Rohatgi R. Nat Chem Biol. 2012 Jan 8;8(2):211-20.

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog - Oxysterol binding to the extracellular domain of Smoothened in Hedgehog

Nedelcu D, Liu J, Xu Y, Jao C, Salic A. Nat Chem Biol. 2013 Sep;9(9):557-64.