27-Hydroxycholesterol

• Supplier: Tocris Bioscience
• Catalog: 4474
• Prices: $279.00
• Sizes: 10 mg
• Function Type: Agonist
• Cas Number: 20380-11-4
• Chemical Name: (3β,25R)-Cholest-5-ene-3,26-diol
• Formula: C27H46O2
• Molecular Weight: 402.65
• Purity: >98 %
• Description: Liver X receptor (LXR) agonist. Also estrogen receptor partial agonist. Suppresses β -estradiol -mediated breast cancer cell proliferation in vitro . Also increases α -synuclein levels and induces apoptosis in human neuroblastoma cells in vitro . Endogenous cholesterol metabolite.

Product References

Natural occurrence of trans-gamma hydroxycrotonic acid in rat brain. - Natural occurrence of trans-gamma hydroxycrotonic acid in rat brain.

Vayer P, Dessort D, Bourguignon JJ, Wermuth CG, Mandel P, Maitre M. Biochem Pharmacol. 1985 Jul 1;34(13):2401-4.

Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies. - Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies.

Bourguignon JJ, Schoenfelder A, Schmitt M, Wermuth CG, Hechler V, Charlier B, Maitre M. J Med Chem. 1988 May;31(5):893-7.

gamma-Hydroxybutyrate ligands possess antidopaminergic and neuroleptic-like - gamma-Hydroxybutyrate ligands possess antidopaminergic and neuroleptic-like

Hechler V, Peter P, Gobaille S, Bourguignon JJ, Schmitt M, Ehrhardt JD, Mark J, Maitre M. J Pharmacol Exp Ther. 1993 Mar;264(3):1406-14.