6-Hydroxy- DL -DOPA

Name 6-Hydroxy- DL -DOPA
Supplier Tocris Bioscience
Catalog 0538
Prices $189.00, $765.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 21373-30-8
Chemical Name 2,5-Dihydroxy-DL-tyrosine
Formula C9H11NO5
Molecular Weight 213.19
Description Allosteric inhibitor of RAD52; inhibits RAD52 binding to single strand DNA binding domains (IC 50 = 1.1 μ M). Selectively inhibits proliferation of BRCA-deficient cancer cells in vitro . Also inhibits APE1.
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Product References

Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for - Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for

Breese GR, Traylor TD. J Pharmacol Exp Ther. 1970 Sep;174(3):413-20.

Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some - Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some

Soto-Otero R, Mendez-Alvarez E, Hermida-Ameijeiras A, Munoz-Patino AM, Labandeira-Garcia JL. J Neurochem. 2000 Apr;74(4):1605-12.

Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 - Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12

Fujita H, Ogino T, Kobuchi H, Fujiwara T, Yano H, Akiyama J, Utsumi K, Sasaki J. Brain Res. 2006 Oct 3;1113(1):10-23. Epub 2006 Aug 30.