( Z )-4-Hydroxytamoxifen

Name ( Z )-4-Hydroxytamoxifen
Supplier Tocris Bioscience
Catalog 0245
Prices $175.00, $709.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 68047-06-3
Chemical Name 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
Formula C26H29NO2
Molecular Weight 387.51
Purity >98 %
Description Estrogen receptor antagonist. Tamoxifen (Cat. No. 0999) metabolite; exhibits greater potency than the parent compound. Chemotherapeutic agent. Also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing; system has ~25-fold higher specificity than wtCas9.
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Product References

A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. - A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity.

Jordan VC, Collins MM, Rowsby L, Prestwich G. J Endocrinol. 1977 Nov;75(2):305-16.

Simple and efficient production of (Z)-4-hydroxytamoxifen, a potent estrogen - Simple and efficient production of (Z)-4-hydroxytamoxifen, a potent estrogen

Yu DD, Forman BM. J Org Chem. 2003 Nov 28;68(24):9489-91.

Comprehensive evaluation of tamoxifen sequential biotransformation by the human - Comprehensive evaluation of tamoxifen sequential biotransformation by the human

Desta Z, Ward BA, Soukhova NV, Flockhart DA. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75. Epub 2004 May 24.