Hygromycin B

Name Hygromycin B
Supplier Tocris Bioscience
Catalog 3412
Prices $49.00
Sizes 50 mg
Cas Number 31282-04-9
Chemical Name O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine
Formula C20H37N3O13
Molecular Weight 527.52
Purity >90 %
Description Aminoglycoside antibiotic. Active against both prokaryotic and eukaryotic cells. Inhibits protein synthesis by binding to the 30S subunit and inhibiting the ribosomal translocation step of elongation.
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Product References

Hygromycin B phosphotransferase as a selectable marker for DNA transfer - Hygromycin B phosphotransferase as a selectable marker for DNA transfer

Blochlinger K, Diggelmann H. Mol Cell Biol. 1984 Dec;4(12):2929-31.

The structural basis for the action of the antibiotics tetracycline, pactamycin, - The structural basis for the action of the antibiotics tetracycline, pactamycin,

Brodersen DE, Clemons WM Jr, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V. Cell. 2000 Dec 22;103(7):1143-54.

A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli - A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli

Ganoza MC, Kiel MC. Antimicrob Agents Chemother. 2001 Oct;45(10):2813-9.