10 Z -Hymenialdisine

• Supplier: Tocris Bioscience
• Catalog: 4137
• Prices: $329.00
• Sizes: 500 µg
• Function Type: Inhibitor
• Cas Number: 82005-12-7
• Chemical Name: (4Z)-4-(2-Amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one
• Formula: C11H10BrN5O2
• Molecular Weight: 324.13
• Purity: >97 %
• Description: Pan kinase inhibitor (IC 50 values are 6, 10, 22, 28, 35, 40, 70, 80, 100, 470, 500, 600, 700 and 700 nM for MEK1, GSK-3 β , Cdk1/cyclin B, Cdk5/p25, CK1, Cdk2/cyclin A, Cdk2/cyclin E, ASK- γ , Cdk3/cyclin E, Erk1, PKC γ , Cdk4/cyclin D1, Cdk6/cyclin D2 and PKC α respectively.) Inhibits NF- κ B activation and blocks IL-8 production in U937 cells (IC 50 values are 1-2 and 0.34-0.48 μ M respectively).

Product References

The natural product hymenialdisine inhibits interleukin-8 production in U937 - The natural product hymenialdisine inhibits interleukin-8 production in U937

Breton JJ, Chabot-Fletcher MC. J Pharmacol Exp Ther. 1997 Jul;282(1):459-66.

Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a - Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a

Meijer L, Thunnissen AM, White AW, Garnier M, Nikolic M, Tsai LH, Walter J, Cleverley KE, Salinas PC, Wu YZ, Biernat J, Mandelkow EM, Kim SH, Pettit GR. Chem Biol. 2000 Jan;7(1):51-63.

Aldisine alkaloids from the Philippine sponge Stylissa massa are potent - Aldisine alkaloids from the Philippine sponge Stylissa massa are potent

Tasdemir D, Mallon R, Greenstein M, Feldberg LR, Kim SC, Collins K, Wojciechowicz D, Mangalindan GC, Concepcion GP, Harper MK, Ireland CM. J Med Chem. 2002 Jan 17;45(2):529-32.