| Name | I-BET 151 dihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1086 |
| Prices | $225.00, $925.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1883545-47-8 |
| Chemical Name | 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-onedihydrochloride |
| Formula | C23H21N5O3.2HCl |
| Molecular Weight | 488.37 |
| Purity | >98 % |
| Description | BET bromodomain inhibitor; blocks recruitment of BET to chromatin. Induces apoptosis and G 0 /G 1 cell cycle arrest in MLL-fusion leukemic cell lines in vitro (IC 50 values are 15, 26, 120 and 192 nM for NOMO1, MV4;11, MOLM13 and RS4;11 cell lines respectively); reduces BCL2 expression in NOMO1 cells. Improves survival in two rodent models of MLL-fusion leukemia in vivo . Enhances differentiation of human iPSC into megakaryocytes. |
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