ICA 069673

• Supplier: Tocris Bioscience
• Catalog: 3908
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Cas Number: 582323-16-8
• Chemical Name: N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
• Formula: C11H6ClF2N3O
• Molecular Weight: 269.63
• Purity: >99 %
• Description: Selective K V 7.2/K V 7.3 (KCNQ2/3) channel opener (EC 50 = 0.69 μ M). Exhibits 20-fold selectivity for K V 7.2/K V 7.3 over K V 7.3/K V 7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.