ICG 001

• Supplier: Tocris Bioscience
• Catalog: 4891
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 847591-62-2
• Chemical Name: (6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
• Formula: C33H32N4O4
• Molecular Weight: 548.63
• Purity: >98 %
• Description: Inhibitor of TCF/ β -catenin-mediated transcription. Selectively inhibits β -catenin/CBP interaction; displays no effect on β -catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.

Product References

A small molecule inhibitor of beta-catenin/CREB-binding protein transcription - A small molecule inhibitor of beta-catenin/CREB-binding protein transcription

Emami KH, Nguyen C, Ma H, Kim DH, Jeong KW, Eguchi M, Moon RT, Teo JL, Kim HY, Moon SH, Ha JR, Kahn M. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12682-7. Epub 2004 Aug 16.

Targeting Wnt signaling in colon cancer stem cells. - Targeting Wnt signaling in colon cancer stem cells.

de Sousa EM, Vermeulen L, Richel D, Medema JP. Clin Cancer Res. 2011 Feb 15;17(4):647-53.

Interactions between beta-catenin and transforming growth factor-beta signaling - Interactions between beta-catenin and transforming growth factor-beta signaling

Zhou B, Liu Y, Kahn M, Ann DK, Han A, Wang H, Nguyen C, Flodby P, Zhong Q, Krishnaveni MS, Liebler JM, Minoo P, Crandall ED, Borok Z. J Biol Chem. 2012 Mar 2;287(10):7026-38.