ICI 118,551 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4505
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 72795-01-8
• Chemical Name: (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
• Formula: C17H27NO2.HCl
• Molecular Weight: 313.87
• Purity: >98 %
• Description: Very selective β 2 adrenergic antagonist/inverse agonist (K i values are 1.2, 120 and 257 nM for β 2 , β 1 and β 3 receptors respectively). Active in vivo . Also available as part of the β -Adrenoceptor Antagonist Tocriset™ .

Product References

The pharmacology of a beta 2-selective adrenoceptor antagonist (ICI 118,551). - The pharmacology of a beta 2-selective adrenoceptor antagonist (ICI 118,551).

Bilski AJ, Halliday SE, Fitzgerald JD, Wale JL. J Cardiovasc Pharmacol. 1983 May-Jun;5(3):430-7.

Beta-adrenoceptor subtypes and the opening of plasmalemmal K(+)-channels in - Beta-adrenoceptor subtypes and the opening of plasmalemmal K(+)-channels in

Cook SJ, Small RC, Berry JL, Chiu P, Downing SJ, Foster RW. Br J Pharmacol. 1993 Aug;109(4):1140-8.

Beta 2- but not beta 3-adrenoceptors mediate prejunctional inhibition of - Beta 2- but not beta 3-adrenoceptors mediate prejunctional inhibition of

Ten Berge RE, Weening EC, Roffel AF, Zaagsma J. Eur J Pharmacol. 1995 Mar 6;275(2):199-206.

Function and regulation of the beta 3-adrenoceptor. - Function and regulation of the beta 3-adrenoceptor.

Strosberg AD, Pietri-Rouxel F. Trends Pharmacol Sci. 1996 Oct;17(10):373-81.