ICI 182,780

• Supplier: Tocris Bioscience
• Catalog: 0820
• Prices: $95.00, $199.00, $825.00
• Sizes: 1 mg, 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 129453-61-8
• Chemical Name: 7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol
• Formula: C32H47F5O3S
• Molecular Weight: 606.77
• Purity: >99 %
• Description: A high affinity estrogen receptor antagonist (IC 50 = 0.29 nM), devoid of any partial agonism both in vitro and in vivo . Also high affinity agonist at the membrane estrogen receptor GPER.

Product References

A potent specific pure antiestrogen with clinical potential. - A potent specific pure antiestrogen with clinical potential.

Wakeling AE, Dukes M, Bowler J. Cancer Res. 1991 Aug 1;51(15):3867-73.

Comparison between novel steroid-like and conventional nonsteroidal - Comparison between novel steroid-like and conventional nonsteroidal

de Cupis A, Noonan D, Pirani P, Ferrera A, Clerico L, Favoni RE. Br J Pharmacol. 1995 Nov;116(5):2391-400.

ICI 182,780 (Faslodex): development of a novel, "pure" antiestrogen. - ICI 182,780 (Faslodex): development of a novel, "pure" antiestrogen.

Howell A, Osborne CK, Morris C, Wakeling AE. Cancer. 2000 Aug 15;89(4):817-25.

Identity of an estrogen membrane receptor coupled to a G protein in human breast - Identity of an estrogen membrane receptor coupled to a G protein in human breast

Thomas P, Pang Y, Filardo EJ, Dong J. Endocrinology. 2005 Feb;146(2):624-32. Epub 2004 Nov 11.