ICI 63197

• Supplier: Tocris Bioscience
• Catalog: 0929
• Prices: $139.00, $579.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 27277-00-5
• Chemical Name: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one
• Formula: C9H13N5O
• Molecular Weight: 207.23
• Purity: >99 %
• Description: Potent phosphodiesterase (PDE) 4 inhibitor (IC 50 = 35 nM for inhibition of [ 3 H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo .

Product References

Potential antidepressant activity of rolipram and other selective cyclic - Potential antidepressant activity of rolipram and other selective cyclic

Wachtel H. Neuropharmacology. 1983 Mar;22(3):267-72.

Autoradiographic mapping of a selective cyclic adenosine monophosphate - Autoradiographic mapping of a selective cyclic adenosine monophosphate

Kaulen P, Bruning G, Schneider HH, Sarter M, Baumgarten HG. Brain Res. 1989 Dec 4;503(2):229-45.

Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using - Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using

Zhao Y, Zhang HT, O'Donnell JM. J Pharmacol Exp Ther. 2003 May;305(2):565-72.