IDE 2

• Supplier: Tocris Bioscience
• Catalog: 4015
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Inducer
• Cas Number: 1136466-93-7
• Chemical Name: Heptanedioicacid-1-(2-cyclopentylidenehydrazide)
• Formula: C12H20N2O3
• Molecular Weight: 240.3
• Purity: >98 %
• Description: Cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC 50 = 223 nM for induction of Sox17 expression in ESCs). Reported to activate TGF- β signaling and downstream Smad2 phosphorylation; upregulates Nodal expression. Promotes pancreatic progenitor cell formation in vitro , and gut tube formation in vivo .

Product References

Small molecules efficiently direct endodermal differentiation of mouse and human - Small molecules efficiently direct endodermal differentiation of mouse and human

Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA. Cell Stem Cell. 2009 Apr 3;4(4):348-58.

Using small molecules to great effect in stem cell differentiation. - Using small molecules to great effect in stem cell differentiation.

Zaret KS. Cell Stem Cell. 2009 May 8;4(5):373-4.

Stimulation of Activin A/Nodal signaling is insufficient to induce definitive - Stimulation of Activin A/Nodal signaling is insufficient to induce definitive

Filby CE, Williamson R, van Kooy P, Pebay A, Dottori M, Elwood NJ, Zaibak F. Stem Cell Res Ther. 2011 Apr 4;2(2):16.