IEM 1460

• Supplier: Tocris Bioscience
• Catalog: 1219
• Prices: $109.00, $459.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 121034-89-7
• Chemical Name: N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromidehydrobromide
• Formula: C19H37N2Br.HBr
• Molecular Weight: 454.33
• Purity: >98 %
• Description: Voltage-dependent open-channel blocker of AMPA receptors. Selective for GluR2 subunit-lacking (Ca 2+ -permeable) receptors over GluR2-containing receptors (IC 50 values are 2.6 and 1102 μ M, respectively). Selectively blocks fast spiking interneuron but not medium spiny projection neuron in mouse striatum. Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo .

Product References

Characterization of AMPA receptor populations in rat brain cells by the use of - Characterization of AMPA receptor populations in rat brain cells by the use of

Buldakova SL, Vorobjev VS, Sharonova IN, Samoilova MV, Magazanik LG. Brain Res. 1999 Oct 30;846(1):52-8.

Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type - Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type

Schlesinger F, Tammena D, Krampfl K, Bufler J. Br J Pharmacol. 2005 Jul;145(5):656-63.

Selective inhibition of striatal fast-spiking interneurons causes dyskinesias. - Selective inhibition of striatal fast-spiking interneurons causes dyskinesias.

Gittis AH, Leventhal DK, Fensterheim BA, Pettibone JR, Berke JD, Kreitzer AC. J Neurosci. 2011 Nov 2;31(44):15727-31.