IEM 1754 dihydrobromide

• Supplier: Tocris Bioscience
• Catalog: 1636
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 162831-31-4
• Chemical Name: N-(Tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1,5-pentanediaminedihydrobromide
• Formula: C16H30N2.2HBr
• Molecular Weight: 412.25
• Purity: >98 %
• Description: Voltage-dependent open-channel blocker of AMPA receptors. Selective between subtypes; blocks GluR2 subunit-lacking (Ca 2+ -permeable) receptors more potently than GluR2-containing receptors. Also potently blocks NMDA receptor channels. Less sensitive than IEM 1460 (Cat. No. 1460) at a holding potential between -40 and -80mV.

Product References

Block of open channels of recombinant AMPA receptors and native AMPA/kainate - Block of open channels of recombinant AMPA receptors and native AMPA/kainate

Magazanik LG, Buldakova SL, Samoilova MV, Gmiro VE, Mellor IR, Usherwood PN. J Physiol. 1997 Dec 15;505 ( Pt 3):655-63.

Voltage-dependent block of native AMPA receptor channels by dicationic compounds. - Voltage-dependent block of native AMPA receptor channels by dicationic compounds.

Tikhonov DB, Samoilova MV, Buldakova SL, Gmiro VE, Magazanik LG. Br J Pharmacol. 2000 Jan;129(2):265-74.