| Name | (+)-Igmesine hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2892 |
| Prices | $255.00, $1,045.00 |
| Sizes | 10 mg, 50 mg |
| Cas Number | 130152-35-1 |
| Chemical Name | (R)-(+)-N-Cyclopropylmethyl-α-ethyl-N-methyl-α-[(2E)-3-phenyl-2-propenyl)benzenemethanaminehydrochloride |
| Formula | C23H29N.HCl |
| Molecular Weight | 355.94 |
| Purity | >98 % |
| Description | Selective σ 1 receptor ligand (K D = 19.1 nM), with little or no activity at σ 2 receptors (IC 50 > 1000 nM). Inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner (IC 50 value is approximately 100 nM). Weak inhibitor of brain 5-HT uptake in vitro . Exhibits neuroprotective and antidepressant effects. |
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O'Neill M, Caldwell M, Earley B, Canney M, O'Halloran A, Kelly J, Leonard BE, Junien JL. Eur J Pharmacol. 1995 Sep 5;283(1-3):217-25.
Akunne HC, Zoski KT, Whetzel SZ, Cordon JJ, Brandon RM, Roman F, Pugsley TA. Neuropharmacology. 2001 Jul;41(1):138-49.