| Name | Iloprost |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2539 |
| Prices | $299.00 |
| Sizes | 1 mg |
| Cas Number | 78919-13-8 |
| Chemical Name | (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]pentanoicacid |
| Formula | C22H32O4 |
| Molecular Weight | 360.49 |
| Purity | >97 % |
| Description | Prostacyclin (PGI 2 ) analog that binds with high affinity to IP, EP 1 and EP 3 receptors (K i values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP 1 , EP 3 , EP 4 , FP, DP, EP 2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC 50 values are 0.24, 0.71 and 1.07 nM respectively). |
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Abramovitz M, Adam M, Boie Y, Carriere M, Denis D, Godbout C, Lamontagne S, Rochette C, Sawyer N, Tremblay NM, Belley M, Gallant M, Dufresne C, Gareau Y, Ruel R, Juteau H, Labelle M, Ouimet N, Metters KM. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93.
Della Bella S, Molteni M, Mocellin C, Fumagalli S, Bonara P, Scorza R. Prostaglandins Other Lipid Mediat. 2001 Jun;65(2-3):73-83.