iMAC2

• Supplier: Tocris Bioscience
• Catalog: 2038
• Prices: $205.00, $845.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 335166-00-2
• Chemical Name: 3,6-Dibromo-9-[2-fluoro-3-(1-piperazinyl)propyl]-9H-carbazoledihydrochloride
• Formula: C19H20Br2FN3.2HCl
• Molecular Weight: 542.11
• Purity: >98 %
• Description: Inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC 50 = 28 nM). Reduces STS-induced apoptosis in FL5.12 cells by over 50%. Inhibits release of cytochrome c by Bid-induced Bax activation (IC 50 = 0.68 μ M).

Product References

3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of - 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of

Bombrun A, Gerber P, Casi G, Terradillos O, Antonsson B, Halazy S. J Med Chem. 2003 Oct 9;46(21):4365-8.

MAC inhibitors suppress mitochondrial apoptosis. - MAC inhibitors suppress mitochondrial apoptosis.

Peixoto PM, Ryu SY, Bombrun A, Antonsson B, Kinnally KW. Biochem J. 2009 Oct 12;423(3):381-7.