Imetit dihydrobromide

• Supplier: Tocris Bioscience
• Catalog: 5126
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 32385-58-3
• Chemical Name: 5-[2-(Imidazol-4-yl)ethyl]isothioureadihydrobromide
• Formula: C6H10N4S.2HBr
• Molecular Weight: 332.06
• Purity: >98 %
• Description: An extremely potent, high affinity agonist at H 3 and H 4 receptors (K i values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC 50 of 25 nM. Centrally active following systemic administration. Also available as part of the Histamine H 3 Receptor Tocriset™ .

Product References

S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 - S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3

Garbarg M, Arrang JM, Rouleau A, Ligneau X, Tuong MD, Schwartz JC, Ganellin CR. J Pharmacol Exp Ther. 1992 Oct;263(1):304-10.

Influence of different histamine receptor agonists and antagonists on - Influence of different histamine receptor agonists and antagonists on

Farzin D, Attarzadeh M. Eur J Pharmacol. 2000 Sep 15;404(1-2):169-74.

Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and - Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and

Ling P, Ngo K, Nguyen S, Thurmond RL, Edwards JP, Karlsson L, Fung-Leung WP. Br J Pharmacol. 2004 May;142(1):161-71.