Impentamine dihydrobromide

• Supplier: Tocris Bioscience
• Catalog: 2315
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 149629-70-9
• Chemical Name: 4-(5-Aminopentyl)imidazoledihydrobromide
• Formula: C8H15N3.2HBr
• Molecular Weight: 315.05
• Description: Potent and highly selective histamine H 3 receptor antagonist (pA 2 = 8.4); displays > 30000-fold selectivity over H 1 and H 2 receptors. Can act as a partial agonist in SK-N-MC cells expressing human H 3 receptors. Produces antinociception, possibly via a non-H 1 , -H 2 or -H 3 receptor-mediated mechanism, following central administration in vivo .

Product References

Homologs of histamine as histamine H3 receptor antagonists: a new potent and - Homologs of histamine as histamine H3 receptor antagonists: a new potent and

Vollinga RC, Menge WM, Leurs R, Timmerman H. J Med Chem. 1995 Jan 20;38(2):266-71.

Antinociceptive activity of impentamine, a histamine congener, after CNS - Antinociceptive activity of impentamine, a histamine congener, after CNS

Hough LB, Nalwalk JW, Leurs R, Menge WM, Timmerman H. Life Sci. 1999;64(5):PL79-86.

Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC - Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC

Wieland K, Bongers G, Yamamoto Y, Hashimoto T, Yamatodani A, Menge WM, Timmerman H, Lovenberg TW, Leurs R. J Pharmacol Exp Ther. 2001 Dec;299(3):908-14.