Indibulin

Name Indibulin
Supplier Tocris Bioscience
Catalog 1588
Prices $159.00, $665.00
Sizes 10 mg, 50 mg
Cas Number 204205-90-3
Chemical Name 2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide
Formula C22H16ClN3O2
Molecular Weight 389.83
Purity >98 %
Description Microtubule destabilizer that blocks tubulin polymerization (IC 50 = 0.3 μ M). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC 50 values ranging from 0.036 - 0.285 μ M). Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo . Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules. Displays oral availability and efficacy towards MDR tumor cells.
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Product References

D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral - D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral

Bacher G, Nickel B, Emig P, Vanhoefer U, Seeber S, Shandra A, Klenner T, Beckers T. Cancer Res. 2001 Jan 1;61(1):392-9.

Microtubule inhibitor D-24851 induces p53-independent apoptotic cell death in - Microtubule inhibitor D-24851 induces p53-independent apoptotic cell death in

Ito H, Kanzawa T, Kondo S, Kondo Y. Int J Oncol. 2005 Mar;26(3):589-96.

Indibulin, a novel microtubule inhibitor, discriminates between mature neuronal - Indibulin, a novel microtubule inhibitor, discriminates between mature neuronal

Wienecke A, Bacher G. Cancer Res. 2009 Jan 1;69(1):171-7.