Indiplon

• Supplier: Tocris Bioscience
• Catalog: 3728
• Prices: $139.00, $579.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 325715-02-4
• Chemical Name: N-Methyl-N-[3-[3-[2-thienylcarbonyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide
• Formula: C20H16N4O2S
• Molecular Weight: 376.43
• Purity: >99 %
• Description: Potent GABA A receptor positive allosteric modulator that acts at the benzodiazepine site (K i values are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively). Displays ~ 10-fold selectivity for α 1 subunit-containing receptors (EC 50 values are 2.6, 24, 60 and 77 nM for α 1 β 2 γ 2, α 2 β 2 γ 2, α 3 β 3 γ 2 and α 5 β 2 γ 2 receptors respectively). Exhibits sedative, hypnotic, anxiolytic and anticonvulsant activity in vivo and is orally active.

Product References

In vivo pharmacological characterization of indiplon, a novel pyrazolopyrimidine - In vivo pharmacological characterization of indiplon, a novel pyrazolopyrimidine

Foster AC, Pelleymounter MA, Cullen MJ, Lewis D, Joppa M, Chen TK, Bozigian HP, Gross RS, Gogas KR. J Pharmacol Exp Ther. 2004 Nov;311(2):547-59. Epub 2004 Jul 15.

Characterization of the interaction of indiplon, a novel pyrazolopyrimidine - Characterization of the interaction of indiplon, a novel pyrazolopyrimidine

Sullivan SK, Petroski RE, Verge G, Gross RS, Foster AC, Grigoriadis DE. J Pharmacol Exp Ther. 2004 Nov;311(2):537-46. Epub 2004 Jul 15.

Indiplon is a high-affinity positive allosteric modulator with selectivity for - Indiplon is a high-affinity positive allosteric modulator with selectivity for

Petroski RE, Pomeroy JE, Das R, Bowman H, Yang W, Chen AP, Foster AC. J Pharmacol Exp Ther. 2006 Apr;317(1):369-77. Epub 2006 Jan 6.