Indirubin-3'-oxime

• Supplier: Tocris Bioscience
• Catalog: 3597
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 160807-49-8
• Chemical Name: 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
• Formula: C16H11N3O2
• Molecular Weight: 277.28
• Purity: >99 %
• Description: Protein kinase inhibitor; inhibits cyclin-dependent kinases (IC 50 = 0.18 - 3.33 μ M) and GSK-3 β (IC 50 = 0.19 μ M). Inhibits CDK5- and GSK-3 β -mediated tau phosphorylation, a process over-active in Alzheimer disease states. Also inhibits AMPK, LCK and SGK. Induces cell cycle arrest and inhibits cell proliferation.

Product References

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits - Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits

Hoessel R, Leclerc S, Endicott JA, Nobel ME, Lawrie A, Tunnah P, Leost M, Damiens E, Marie D, Marko D, Niederberger E, Tang W, Eisenbrand G, Meijer L. Nat Cell Biol. 1999 May;1(1):60-7.

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein - Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein

Leclerc S, Garnier M, Hoessel R, Marko D, Bibb JA, Snyder GL, Greengard P, Biernat J, Wu YZ, Mandelkow EM, Eisenbrand G, Meijer L. J Biol Chem. 2001 Jan 5;276(1):251-60.

The specificities of protein kinase inhibitors: an update. - The specificities of protein kinase inhibitors: an update.

Bain J, McLauchlan H, Elliott M, Cohen P. Biochem J. 2003 Apr 1;371(Pt 1):199-204.